The project is implemented using the funding of the State Research Program.
Project name: "National Research Program Project in Biomedicine, Medical Technologies and Pharmacy"
Project no. VPP-EM-BIOMEDICINA-2022/1-0001.
Polygenic risk
Polygenic risk refers to the combined effect of several genes on an individual's chance of developing a particular disease or acquiring a particular trait. Unlike monogenic diseases, which are caused by a mutation in a single gene, polygenic diseases and traits are the result of the interaction of multiple genes, where each gene makes a small contribution.
Polygenic Risk Score (PRS)
PRS is a numerical value that quantifies an individual's genetic predisposition to a particular trait or disease based on the sum of risk gene variants (alleles) taking into account the effect sizes of these alleles.
PRS is calculated using data from genome-wide genetic association studies (GWAS), which identify the most common genetic variants associated with specific traits.
Application of polygenic risk number
PRS can help predict the risk of developing complex diseases such as heart disease, diabetes and certain types of cancer.
PRS can be applied in personalized medicine to tailor therapy and preventive measures based on an individual's genetic risk.